−, and reduced multiple measures of their pathogenicity in vitro, including proliferation and invasion.PEG‐HCCs were internalized by RA‐FLS, reduced their intracellular O2 We used the pristane‐induced arthritis (PIA) rat model of RA to assess the benefits of PEG‐HCCs on reducing disease severity. We used human FLS from patients with RA to determine PEG‐HCC internalization and effects on FLS cytotoxicity, invasiveness, proliferation, and production of proteases. −) and hydroxyl radicals with antioxidant nanoparticles, called poly(ethylene glycol)‐functionalized hydrophilic carbon clusters (PEG‐HCCs), on the pathogenic functions of fibroblast‐like synoviocytes (FLS) from patients with rheumatoid arthritis (RA) and on the progression of an animal model of RA.Our goal was to determine the effects of selectively scavenging superoxide (O2 Reactive oxygen species have been involved in the pathogenesis of rheumatoid arthritis (RA).
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